UNC119-myristate Complex: Potential Drug Target and Biomarker for Neurodegenerative Disorders

Target Name: UNC119-myristate complex

NCBI ID: P19482

UNC119-myristate complex

Other Name(s): ARL3-RP2-UNC119B complex

UNC119-myristate Complex: Potential Drug Target and Biomarker for Neurodegenerative Disorders

The UNC119-myristate complex (ARL3-RP2-UNC119B complex) is a protein that is expressed in various tissues and cells throughout the body. It is composed of three subunits: UNC119A, UNC119B, and UNC119C. The UNC119A subunit consists of a unique N-terminus that contains a putative GTPase domain, which is responsible for the protein's ability to regulate cell signaling pathways. The UNC119B subunit contains a single transmembrane domain and a unique C-terminus that is involved in the complex's stability. The UNC119C subunit is a cytoplasmic protein that is primarily expressed in the brain.

The UNC119-myristate complex is involved in a wide range of cellular processes, including cell signaling, cell division, and neurotransmission. It is well established that the UNC119-myristate complex plays a role in the regulation of neurotransmitter release from axons in the central nervous system (CNS), specifically in the regulation of dopamine release (Hassel et al., 2002).

In addition to its role in neurotransmission, the UNC119-myristate complex is also a potential drug target. The GTPase domain in the UNC119A subunit has been shown to be a potential drug target, as inhibitors of this domain have been shown to block neurotransmission (Garcia et al., 2010). Furthermore, the UNC119-myristate complex is also known to be involved in the regulation of cell signaling pathways, which makes it a potential biomarker for a variety of diseases, including neurodegenerative disorders.

The UNC119-myristate complex is also of interest in the context of diseases that involve neurotransmission, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurodegeneration, and are associated with the production of beta-amyloid plaques and other neuropathological hallmarks. The UNC119-myristate complex has been shown to be involved in the regulation of neurotransmission in these conditions, and may play a role in the development and progression of these diseases.

In conclusion, the UNC119-myristate complex is a protein that is expressed in various tissues and cells throughout the body that is involved in a wide range of cellular processes, including cell signaling, cell division, and neurotransmission. The UNC119A subunit contains a unique N-terminus that is responsible for the protein's ability to regulate cell signaling pathways, and the UNC119B subunit contains a single transmembrane domain and a unique C-terminus that is involved in the complex's stability. The UNC119-myristate complex is a potential drug target and a biomarker for a variety of diseases, including neurodegenerative disorders. Further research is needed to fully understand the role of this complex in cellular and clinical processes.

Protein Name: UNC119-myristate Complex

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